Wellcome Sanger Institute
Sanger Institute Science Collaboration
Research Project
Cancer, Ageing and Somatic Mutation

Genomic characterization of Colorectal Patient-derived Xenografts

In collaboration with the Andrea Bertotti lab at University of Turin we plan to sequence 500 human colorectal PDX models.

About the project

Using a targeted gene screen for 116 colorectal cancer genes, 50 regions recurrently amplified or deleted as well as MSI regions, we will Illumina sequence approx. 500 human colorectal patient-derived xenografts to enable the rapid translation of gene-drug associations observed in the Sanger Institute cell line drug screen or the siKinome and CRISPR/Cas9 lethality screens we are currently undertaking.

Sanger people

Photo of Dr Howard Lightfoot

Dr Howard Lightfoot

Principal Bioinformatician

External Contributors

Photo of Prof Andrea Bertotti MD PhD

Prof Andrea Bertotti MD PhD

Related groups

 

Science group

McDermott Group

Cancer Functional Genomics

Our work is in the understanding of how cancer genomes affect drug sensitivity and resistance.
 
Wellcome Sanger Institute

Programmes and Facilities

 

Programme

Cancer, Ageing and Somatic Mutation

The Cancer, Ageing and Somatic Mutation Programme pioneers data aggregation and informatics innovation, develops high-throughput cellular models of cancer for genome-wide ...