During my master’s program, I developed algorithm and software to improve the accuracy and speed of drug design in silico. I used computer simulation to investigate whether two proteins or protein-molecule can interact with each other. This might give us a pre-knowledge for drug design. 

During my PhD’s program, my major interest is analyzing ageing or age-related traits based on genetic and genomic data. There are three projects: 1) I used a random regression model to detect whether the longitudinal changing rates of DNA methylation varies between individuals. This variation might help us to better understand the different ageing rate between individuals; 2) I developed an age predictor using both the best linear unbiased predictor (BLUP) and elastic net based on the DNA methylation from largest to date samples (N = 13,661). I examined the rationale of using the predicted age as biological age; 3) I used logistic regression and Cox regression to detect the genetic effect on late-onset Alzheimer’s disease (LOAD) and its age at onset. I investigated the genetic architecture of LOAD.