Isabelle Zane
PhD Student
Measuring the effect of mutations on transcription factors
I am a PhD student working on assays to measure the effect of mutations on transcription factors. My research involves deep mutational scanning to generate transcription factor mutants, and next generation sequencing to measure the effect of those mutants. I’m interested in how mutations affect the allostery and binding interfaces of transcription factors, and I am developing the assays to measure this.
Wellcome Sanger Institute