Within Open Targets, Hanna is responsible for the development of new algorithms and computational tools for optimising the genomic characterization of large panels of cancer in vitro models. This involves the design of scoring methods and assessment routines for evaluating the relevance of immortalised cancer cell lines with respect to matched primary diseases. The aim of this work is to enable researchers to make appropriate informed choices about model inclusion/exclusion in retrospective and future studies, and to identify cancer subtypes currently lacking representative in vitro models.